Brightpearl by Sage

We have been using Brightpearl since before I joined the company. Overall it satisfies most of our needs for PO management and order fulfilment. Shortcomings are a lack of visibility of changes made to the PO and SO lines, and there is no way to bundle multiple POs into a single shipment easily, or sea which POs are currently on sea.

Other than that, we can recommend Brightpearl.